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suPAR (soluble urokinase plasminogen activator receptor) is a protein found in blood plasma. suPAR Health offers a research-use-only test that measures your suPAR level to support scientific understanding of immune and inflammatory activity.

Research-Driven. Internationally Validated.

As of Spring 2025, the suPAR test is available in the United States for Research Use Only (RUO). suPAR (soluble urokinase plasminogen activator receptor) has been studied extensively in Europe and globally since its discovery in 1991. Over 1,000 peer-reviewed studies have explored its role in the immune response, inflammation, and systemic stress.

What Is InflammAGE?

Chronic inflammation has been widely studied for its potential role in the aging process, often referred to as 'inflammaging.' This concept explores how immune activity may relate to biological aging.

suPAR levels are being studied as a marker of immune activity. In research settings, they may provide insights into systemic inflammation and its potential relationship to aging.

Studying Inflammation Over Time With suPAR

In research settings, suPAR has been studied as a relatively stable biomarker of immune activity that may respond to environmental or lifestyle changes over time.

In some research studies, suPAR levels have shown changes over 4–12 weeks in association with lifestyle factors. These findings are exploratory and not intended to guide individual health decisions.

A Simple Process to Get Tested

Step 2.
Blood Draw

You can have your blood drawn at your doctor’s office, a local lab, or right at home by a licensed healthcare professional specially trained to draw blood.

Step 3.
Sample Preparation

A centrifuge is used to separate the plasma from your blood sample. The plasma is then prepared for research analysis of suPAR.

Step 1.
Register Your Test

Scan the QR code to securely link your sample to you. If it’s your first time, you’ll create a login to access your results when they’re ready.

Step 4.
Sample Shipment

The healthcare professional who drew your blood will prepare your plasma sample and handle secure shipment to a CLIA-certified laboratory for research processing.

Step 5.
Receive Results

Access your suPAR research results through our secure online portal.

FAQs

  • The soluble urokinase plasminogen activator receptor (suPAR) is a protein released during immune activation. suPAR reflects the body's inflammatory state, making it a universal and stable marker of overall health. Elevated suPAR levels are linked to chronic inflammation, which increases the risk of conditions like cardiovascular disease, kidney disease, and even mortality. Monitoring your suPAR score gives you insights into your health and helps guide proactive changes.

  • The suPAR Health test stands out as a superior biomarker for predicting biological age and inflammation due to its unique ability to reflect the chronic immune activation within the body.

    Unlike other biomarkers that typically capture acute reactions or are specific to certain diseases, suPAR provides a broader, more systemic perspective of an individual's overall health status.

    This global indicator of immune system activation makes it a powerful predictor of biological aging, encapsulating the cumulative effect of lifestyle, environmental exposures, and chronic illnesses.

    Furthermore, suPAR remains stable in the bloodstream, offering consistent and reliable readings, which is crucial for tracking changes over time and assessing the impact of interventions.

    Its predictive capacity for various outcomes, such as cardiovascular events and mortality, surpasses that of many conventional biomarkers, making it an invaluable tool in both clinical and research settings to monitor and manage overall health and inflammation.

  • First, order a suPAR Test to your address.
    The test kit contains:

    • Blood collection tube

    • Step-by-step instructions

    • Barcode labels for secure sample tracking

    • Prepaid shipping materials for easy sample return to the suPAR Health processing laboratory


    Second, take the test. A blood sample may be taken with a RN in your home by coordinating with our mobile phlebotomist network or through a physician clinic who is pioneering suPAR Testing in the United States. Once a blood sample is taken, it will be handled by the medical professional and shipped securely to our processing laboratory.

    Third, receive your suPAR Test results in approximately 7 days via a HIPAA Protected PDF file in your email.

  • The suPAR Health Test is highly reliable, offering superior stability and predictive power compared to traditional inflammation markers like CRP or IL-6. It consistently reflects systemic chronic inflammation without being influenced by short-term illnesses, stress, or circadian fluctuations. Its accuracy is validated across 1,000+ clinical studies, using the suPARnostic® assay known for its precision and reproducibility.

    Unlike CRP, which measures acute inflammation and fluctuates significantly, suPAR provides a stable, long-term indicator of health. It is strongly associated with chronic conditions like cardiovascular disease, kidney dysfunction, and aging-related decline. Studies also show suPAR is a better predictor of biological age, linking elevated levels with faster aging, organ decline, and cognitive impairments.

    suPAR levels can also be reduced through lifestyle changes such as smoking cessation and increased physical activity, making it a valuable tool for tracking health improvements and managing chronic conditions. Its clinical-grade reliability sets it apart from competitor tests, ensuring unmatched accuracy in predicting long-term health outcomes.

  • suPAR levels can improve significantly with healthy lifestyle changes, such as:

    • Eating a balanced diet

    • Regular physical activity

    • Stress management

    • Quitting smoking

    For example, individuals who quit smoking may see a reduction of approximately 1 ng/mL in suPAR levels within just 4 weeks. To track your progress and understand how your efforts are positively impacting your health, testing every 4–12 weeks is recommended. These consistent improvements reflect the reduction of chronic inflammation and better overall health.